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NIH Scientists Discover Genetic Cause of Rare Allergy to Vibration
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NIH Scientists Discover Genetic Cause of Rare Allergy to Vibration

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nih scientists discover genetic cause of rare allergy to vibration

NIH Scientists Discover Genetic Cause of Rare Allergy to Vibration

NIH Scientists Discover Genetic Cause of Rare Allergy to Vibration

I found this article especially interesting because I think I have this disorder. I have never been able to run or do athletic things, or even dance without experiencing itching like having hundreds of mosquito bites. I get hives if I try to run. If I try to run outside, especially in the sun, it is crazy. I get hives and a rash quickly and want to tear my skin off. I thought I was allergic to sweat. Now I wonder if I am allergic to vibration. I will have to find a DNA health test that lists this disorder and see if I have it.

Scientists at the National Institutes of Health (NIH) and the National Human Genome Research Institute have identified a genetic mutation responsible for a rare form of inherited hives induced by vibration, also known as vibratory urticaria. Running, hand clapping, towel drying or even taking a bumpy bus ride can cause temporary skin rashes in people with this rare disorder. By studying affected families, researchers discovered how vibration promotes the release of inflammatory chemicals from the immune system’s mast cells, causing hives and other allergic symptoms.

Their findings, published online in the New England Journal of Medicine on Feb. 3, suggest that people with this form of vibratory urticaria experience an exaggerated version of a normal cellular response to vibration. The study was led by researchers at the National Institute of Allergy and Infectious Diseases (NIAID) and the National Human Genome Research Institute (NHGRI), both part of NIH.
“Investigating rare disorders such as vibratory urticaria can yield important insights into how the immune system functions and how it reacts to certain triggers to produce allergy symptoms, which can range from mild to debilitating,” said NIAID Director Anthony S. Fauci, M.D. “The findings from this study uncover intriguing new facets of mast cell biology, adding to our knowledge of how allergic responses occur.”

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